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If you compare the average annual lpn salary vs. Rn salary ($94,480), you’re looking at a. Webfeb 25, 2023 · lpns in south carolina earn an average of $46,470 per year or $22. 34 per hour. The percentage of u. s. Lpns who work in south carolina is 1%. Weba significant difference between lpn vs. Rn is that rn nursing programs—even the economical adn degree—are far more expensive than lpn educational programs. Web52 rows · jun 5, 2024 · while they require more schooling, rns enjoy more employment opportunties, broader specialization options, increased responsibility, room for career.